The Metanephrine Free test, or the Plasma Free Metanephrines test, is a diagnostic test that can detect and confirm the presence of Pheochromocytoma. This disease entails a tumour in your adrenal gland tissue. The tumour generally appears in a single adrenal gland, but in some cases, it attacks both your adrenal glands together. This tumour is generally non-cancerous and affects your endocrine system significantly. It produces an excess of hormones known as catecholamines. These hormones further break down into Plasma Free Metanephrines. They are responsible for increasing your blood pressure considerably. Additionally, you will also start showing symptoms like: Severe headache  Tremors  Pallor  Panic attack symptoms  Shortness of breath  Anxiety  Blurry vision Constipation Weight loss, etc. The Plasma Free Metanephrines test gauges the levels of Metanephrines and Normetanephrines in your bloodstream. If the Metanephrine Free test shows a positive result, you have Pheochromocytoma, and its symptoms will be constant. They will get stronger eventually, leading to further complications. Here are a few factors that can worsen your symptoms considerably: Excessive physical work  Labour and delivery  Anxiety or stress Surgery that involves drugs like anaesthesia  Sudden change in body position The disease starts off with high blood pressure and then exhibits the above symptoms. So if you start witnessing constant fluctuations in your blood pressure, it is time to get the Plasma Free Metanephrines test. Here are some other reasons you should take the Metanephrines test now: Family history of  Pheochromocytoma Blood pressure keeps shooting constantly Family history of genetic disorders  Difficulty in controlling your blood pressure with your ongoing treatments Furthermore, the test uses a blood sample and poses no such complications. The test is highly sensitive, and you will need to prepare for it accordingly. Here are some of the things you need to keep in mind before you get the Plasma Free Metanephrines test done: Have a conversation with your healthcare provider first. You might have to stop taking certain prescription medicines, counter drugs, or supplements, so they don't interfere with the test results. You might have to stop taking some medications before taking the Plasma Free Metanephrines test. Keep in mind that you shouldn't just stop taking all medicines altogether. Please consult your healthcare practitioner first to identify drugs that might potentially interfere and then safely push them out of routine for a couple of days. Keep yourself away from emotional or physical stresses since this too can affect your Plasma Free Metanephrines levels. Stay away from foods containing Tyramine (e.g., beers, wines, chocolates, etc.)