The protein, total – serum test helps to determine the nutritional status of an individual. It is usually done as a part of a routine health check-up. It helps to diagnose certain diseases or disorders such as that of the liver or kidney. The protein, total – serum test is done: • As a routine health check-up • In case of unexplained weight loss or fatigue • In case of signs and symptoms of liver diseases • In case of signs and symptoms of kidney diseases