Protein electrophoresis is a test used for measuring specific proteins in the blood. The protein electrophoresis test is often used to detect M proteins. The test may be advised if the person experiences symptoms like unexplained weight loss, bone pain or frequent fractures, fatigue, weakness, constipation, excessive thirst, nausea. The test is used for diagnosis of few cancers (e.g. Multiple Myeloma), Waldenström macroglobulinemia, monoclonal gammopathy of undetermined significance (MGUS), primary amyloidosis, few liver and kidney diseases, certain autoimmune diseases, malnutrition, bone pain, unexplained peripheral neuropathy, new-onset anaemia.